Single-cell sequencing is useful for a number of applications. For example, it can reveal cellular heterogeneity inside complex tissues, such as tumors. It can also provide information about how ...

Initially, cells are dissociated from liver tissues into single-cell suspensions using in vivo enzymatic perfusion or ex vivo digestion methods. The cells of interest are then enriched from the ...

A comprehensive review article titled “Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses,” published in Quantitative Biology, ...

A framework for analyzing single-cell genomics data, in which geometrical properties are harnessed to obtain insights on cellular diversity, including precise clustering, clear visualizations, and ...

Chimeric antigen receptor T cell (CAR-T) therapy is considered one of the landmark achievements of modern medicine. The therapy involves harvesting a patient’s own immune cells, genetically ...

Scientists in the laboratory of Rendong Yang, Ph.D., associate professor of Urology, have developed a new large language model that can interpret transcriptomic data in cancer cell lines more ...